I just thought I would let everyone know that I received 2 replies, plus Marsha's on Thursday's FML. Of the 4 ferrets, all of them exhibited aggression. (That's one I forgot to mention in Popcorn's case) Here's a summary of the two I received: Thelma - Age 3 exhibited other ferret aggression, even to her cagemate with whom she formerly got along with. Other adrenal symptoms present. Adrenal surgery, but symptoms never reversed, psychological or physical. Lucy - "Lucy needed to be caged by herself during the last 6 months of her life. She was an aggressive terror to any other ferret. She was NOT like that when she entered the shelter. 3 adrenal surgeries, and lysodren did not help. ... Lucy just recently passed. The sweetest little girl any human could ever ask for." So, it appears that (with this small subset), it is usually other ferret/pet aggression, with the ferret continuing to be super-sweet to her humans. In Popcorn's case, she continued to get along with Graham just fine. However, she did start attacking the dogs. Completely unprovoked, she would see them across the room and embark upon a compulsive vendetta to nip their ankles. The poor dogs got so that they would see her and jump up on the furniture and sit perfectly still, watching her carefully. If she got near, they would jump down and switch pieces of furniture. What really amazed me in Popcorn's case, was that as well conditioned as she had the dogs (they would jump up on the furniture as soon as they saw her, before she even saw them), as soon as the Lupron started working, they went right back to the old routine of letting her approach and sniff them. Even following her around and sniffing her, just like the old days. I thought that was really interesting. The dogs could SENSE that she had changed. - Nancy ----- Nancy Stephens [log in to unmask] Newark, DE [Posted in FML issue 2843]