Hi Congratulations regarding your new rescues! Regarding their vaccinations, consult the AFA Vaccination Protocols at http://www.ferret.org/vaccination.htm It states- Canine Distemper: Ferrets over 14 weeks of age with no, unknown, or outdated vaccination history: Give a series of two vaccines given at 2 weeks apart, then annually on the anniversary of the last booster. Rabies: Ferrets over 14 weeks of age with no, unknown, or outdated vaccination history: Give 1 ml SQ and then annually. It is a very good idea to separate the rabies and canine distemper vaccinations by a week or two to minimize the load on the ferret's immune system. In the event of a vaccine reaction, you will also be able to isolate the cause of the problem. Happy ferreting! Gina Hart/Sage Ferrets Visit the Sage Ferrets web site at http://www.geocities.com/Petsburgh/1122 [Posted in FML issue 2732]