My ferret Martin had a reaction to his annual distemper vaccine yesterday. I waited the amount of time suggested by the vet (actually, she suggested 20 minutes, I waited 1/2 an hour), and then I took him home and put him in his cage. He started reacting about an hour after he had gotten the vaccine. Scared my pants off, I've never had a ferret reaction to any vaccination before. He got really lethargic and apparently had some bloody stools though all I saw was the blood. He's okay now, he was real out of it all day yesterday. My question: His vet says that now Martin will have to be pretreated before any vaccinations (get an antihistamine) and will have to stay at the vet's the entire day. She says that he will probably react again. This vet is very nice but very cautious about treating ferrets...is this overkill or necessary? I was just wondering b/c I've never had this experience before. Minta [Posted in FML issue 2561]