Could the vets/experts out there please tell me more about why rabies and distemper shots shouldn't be given at the same time? My ferrets have gotten their shots simultaneously in the past, but the vet wasn't a ferret expert. I recently suspected one of my ferrets might have adrenal disease (he's been behaving "romantically" although he's a gib), and was referred by two Madison, WI vets to a third vet as being the local ferret expert; yesterday she gave my possible-adrenal ferret both shots together when he went in for a check-up. I e-mailed a message about this to a friend who runs an area ferret shelter, and she e-mailed back that the shots should not have been given together....then I read another posting regarding this on today's FML. My friend said that the shots should be given at least four days apart, so if there's a reaction I would know which shot caused it. I didn't realize reaction(s) could occur that long after a shot. I'm going to get back to my friend on this, but would also appreciate it if anyone on the FML would help enlighten me further. Has anyone out there actually experienced reactions coming up to four days after the shot(s)? If so, what form could such a reaction take and how should it be handled? We'll be leaving for eight days in Colorado later in the week...what should I tell my pet-sitter to look out for (she's not a ferret expert although she knows and plays with my ferrets)? What should I look out for in the meantime?....my ferret seems fine so far. (The vet's attitude on adrenal was basically "we can wait and see", since he has none of the other signs, although I'll probably have the Tennessee blood panel test done when we get back.) Thanks much for any and all advice. [Posted in FML issue 2433]