Gary, On reading your post on Jeronimo-- It would seem that there is something which is causing physical distress in your ferret. The large lumps you explained could be the spleen or it could be nodes-- your vet perhaps is not familiar with ferret medicine. This might be a good time to research the FAQ's and take them in to him/her, or seek out a more knowledgeable vet. No slam intended, just an option. If this indeed is a "bad" spleen-- I encourage you to have pathology done to determine the cause of the irritation to the spleen. It will tell you whether a prolonged systemic infection caused the condition, or whether you are dealing with lymphoma. In either case the longer you wait, the poorer the chance of Jeronimo having a full recovery. If the spleen is enlarged due to an infection-- then I encourage you to have your vet help and investigate the cause-- otherwise the ferret will just have one less symptom, and you will find your ferret displaying signs of illness again. We have experienced this at the shelter before-- and only after finding the source of infection did the ferret gain it's health back! If the biopsy / pathology shows lymphoma-- then you have options for treatment. I hope this helps -- wishing Jeronimo a speedy recovery. Alicia a shelter Mom [Posted in FML issue 2274]