Hi Dawn, 16 months is a little young for an adrenal problem, though not unheard of. Also, adrenal problem/tumor does not necessarily equal cancer. The majority are benign. And, the ones that are cancerous are often contained, and go no further than the adrenal. In those cases, removal of the gland removes the cancer. Did your vet at least get a tissue sample for analysis to see if there was cancer involved? The drug you're probably using is Lysodren. I have had nothing but bad experiences with Lysodren. Both of my ferrets that were treated with this drug became VERY ill within a week or two as a result of the drug and I had to stop treatment. Our shelter operator says she lost two ferrets due to Lysodren usage and will never use it again. On the other hand, some ferret owners have had good luck with Lysodren. In my opinion, 16 months is too young to consider a lifetime of Lysodren treatement. And, that's what it means, because adrenal tissue is regenerative and if you stop Lysodren treatment, the gland will begin to return to its overactive self. A right adrenal is not inoperable, but it may be so to a less skilled surgeon. Our shelter's vet removes right adrenals with little problem unless it has grown into the vena cava. Maybe it's time to look around for another vet? I have no medical experience, so take all this as simply my personal opinion. For the ferrets, Mike * Michael F. Janke, [log in to unmask] * Secretary, South Florida Ferret Club and Rescue, Inc. * * Visit our web site: http://www.gate.net/~mjanke [Posted in FML issue 2263]