I am not a breeder nor a vet, but the way I understand it... If a Jill comes into heat and you want to spay her and not have babies, the most appropriate response is to utilize the services of a vasectimized hob to take her out of heat, wait a few weeks, then do the spay. While you can spay a ferret while she is in heat, there is a slightly elevated chance of bleeding or other complications due to the increased hormone levels and blood flow to the pelvic area. We have a rescue here that we are playing the waiting game to see if she is whole or not. The above will be our response if she is. -Anne [Posted in FML issue 2040]