>sounds like she has fluid in her lungs ... gets tired quicker ... walking >funny ... retardation?? These reminded me greatly of Ruffle's assorted problems. For those new to the FML Ruffle was lived with multiple handicaps, dealt with intellectual impairment, had a good number of allergies, and suffered from multiple deformities of her skeleton and soft tissues. With great care she made it to 6 years old but at that point she had cardiomyopathy, cystic liver, adrenal and pancreatic problems (the first surgically responsive but the second also required meds), lesions of multiple organs, etc. She was the result of trying to breed for some specialized traits as far as we know. Bruce Williams has a number of her soft tissues and Bob is studying her skeleton. Several possibilities for her problems discussed before folks had much time to study her well (This is still on going) include XY female, absorption of a male fetus when in utero, far too much inbreeding, disease or exposure to some deforming agent in utero or when young, a rare brain disorder, and some others. Don't know quite where this stands now. Chest x-rays certainly ARE called for to eliminate the possibilities of heart disease as well as infection, either of which MUST be treated. Allergies should be considered and Benadryl pediatric liquid tried with vets' approval. Does her nose run a lot, and if so does she have mast cell skin tumors or not? Could you describe her locomotion? Is it a continuous abberation? This is important since the low blood sugar connected to insulinomae will cause on and off problems. Is it a waddle? A stagger? Are some legs weaker than others and if so, which ones? Can she arch her back and how well? Can she run? When she runs is it with a hop or as a skunk would run? Are any of her legs bowed? Are they short but her body problems or early arthritis? Are there other skeletal aspects which are unusual such as a very short face for a female? What leads you to suggest "retardation"? In Ruffle this impairment was always markedly obvious but has someone who has extensive experience with ferret behavior been around her to see if she is impaired in this fashion or in a sensory way? You mention canine distemper but does she have the symptoms of that? (If it is CD then she needs a mercy shot but I have not heard anything definitive on that regard.) Please, get in touch with us. If this little one has Ruffle's types of problems she is going to need a lot of special care and we can either help you or another who wants to tackle such things, or if she is not down with an infectious disease and is ECE free but is suffering from multiple handicaps we'd be happy to provide a home with experience in long term maintenance of such individuals. Our phone number is 1-908-580-0506, and our address is 172 Jamestown Road, Basking Ridge, N.J. 07920. Sukie and Steve Crandall [Posted in FML issue 1912]