Hi FertFamilies: This evening Bonnie is sleepy and a bit standoffish--but she came through her adrenalectomy well and it was the right thing to do. All her blood tests were normal prior to surgery (We did not do the Tennessee panel, just glucose, RBC's etc.). No tumor was palpable, but she looked the victim of prolonged and repeated chemotherapy--with pathetic little tufts of hair all over (do they feel colder this way?). Her left adrenal was 2-3 times normal size and was removed. Examination of the pancreas revealed no problem there at the moment. It did not have any apparent nodules. She has a relatively straight incision mid-ventrally--longer than I thought it would be. Her sutures are all internal to avoid the chance of nibbling, tugging, etc. at them. She was chewing on the cage at the vets--she almost never does this at home but wanted OUT! I have her adrenal in formalin here on my desk! I opted--as suggested by our Florida Ferret friends--to bypass the pathology, although I may do it myself (science types love to look at neat stuff like this!)--as I was reminded that these tumors even if malignant do not metastasize and that if they do there is not much treatment available--so the added expense seemed moot. Many thanks for your insights and stories--they help to know when the time is right to act and I'm glad we did this now before other organ involvement occurred. My vet did not insist Bonnie be isolated from Clyde--so long as they are restful while in the cage together. It is working well--Clyde was frantic on Friday when he could not find Bonnie--pried open the cage top (which he never does) and wandered around the house for half the night rummaging here and there. He would not eat, would not accept treats until later today. But when we brought Bonnie home the first thing he did was eat! They are curled up asleep and cozy right now and are probably settled in for the evening until their usual late night playtime comes around. Then I have to keep Bonnie in the cage. Again, many thanks for your suggestions and solid information about this all-too-common ferret disorder. We are relieved to know we have such a resource and so many knowledgeable and kindly folks to back us up. Regards, Gail, Bob and the kids Bonnie and Clyde :-) [Posted in FML issue 1909]