Living in California, I (of course) do not have ferrets. However, the toe biting may be an early sign of adrenyl lesions. Check for hair loss and swollen vulva. The excessive hormone input can make the sweetest kids agressive. I know a ferret named Fancy (Fancy Ferret Fawcett) who started with toe biting long before the hair loss and other symptoms. I can also recommend a vet in the San Francisco area that has lots of ferret experience, and who performed surgery on Fancy - with a very happy ending. Dr. Lynn Dustin is very gentle with the little critters, also very caring and responsive to frantic phone calls. She called Fancy's mom while on vacation in Santa Barbara three times one Sunday a.m. starting at 7:00 a.m. Nice lady! [Posted in FML issue 1856]