I have been lurking for some time now and have waited to post anything until I received some test results in on my ferret Oreo. Well today I got the answer I was hoping to avoid and now I need help!. Oreo is a four year old spayed MF who keeps going into heat. The first time a local exploratory was done to confirm she was spayed and then she was given depro vera (sp?). Don't ever do that! (More on the interesting side effects in later posts.) Nine months later she finally started to behave normally. The second time we went to a different and better vet and she was given htg and that brought her out of heat. The third time the htg didn't work and extensive surgery was performed and both adrenal glands needed to be removed. She is on flourinef (sp?) and prednisone and for three months she was back to her old self. At the end of September her vulva started swelling and she started loosing hair on her tail and back. Yeah I know, adrenal cancer - but how with no adrenals? My vet is very confident he removed all affected material. The adrenal panel has come back from Tenn. and her estrogen level is way up. He wants to do chemo thru a cathreder (sp?) and is scheduling and ultra sound hopefully this week to see if there is anything to look at - in case the cancer has spread and is visable, he does not want to do any more exploratory surgery on her. He is aware of Lysodren but says it can have side effects and not be effective. Here are my concerns: I want to avoid extreme chemo is I possibly can unless it is necessary to her health. I do not know what quality of life she can expect to have - I can't find anything at all on ferrets with adrenal problems *after* a bilateral adrenalectomy. She does not seem to be suffering any ill effects now but how long can she go until anemia is a problem? I check her color all the time and watch her energy level. Another concern I have is that the last time she needed to be put out for the blood draw she started foaming at the mouth and my vet decided to clip her nails instead of risking a more serious reaction to the anethstesia(sp?). She has never before reacted this way and I'm concerned about putting her out for the ultrasound. Sorry this is so long but I need to know my options before the end of the week and I am running into dead ends as far as collecting any more information. Anyone who could help me out with info would be greatly appreciated! Sincerely, Pam Franklin Oreo - What do you mean I'm sick? I feel fine! Fluffy - How come she always gets to go ride in the car? Chubba Wubba - Even though I'm fixed she sure smells interesting! Big Foot - Where is all her fur going? [Posted in FML issue 1773]