I am a vet-tech at a local clinic and a grad student at the UGA vet-school here in Athens, GA. The company who makes Frontline is located here in Athens, Rhone Meriex. (I think that is how you spell it). None-the-less, I have a ferret...I love her dearly and I too am hesitant about using frontline on her...The head tech, the staff veterinarians, and I have all called RM and asked about using Frontline on ferrets...There has been no research done specifically on ferrets...But, if you know anything about neuroanatomy, Frontline, ONLY works on invertabrates, i.e. insects...NOT mammals...The only reason why I have not used it on her yet is that she has lost some hair around her rump. We are still trying to figure out whether this is a nutritional, hypersensitivity, or adrenal problem...So, I don't want to put anything on her skin that might possibly affect her skin or haircoat, or make her itch more or less....Basically, trying to eliminate variable... But, I do plan on getting her on Frontline as soon as we figure out what is going on... Take care Lance [Posted in FML issue 1670]