We were given a prescription of prednisolone/prelone syrup to adminster to our ferret. It was clearly upseting her stomach and was impossible to get into her without unbelievable stress though we tried many different methods. The stress was doing her no good as she was very weak and it seemed to contribute to her nausea as well which wasn't good as she needed food desperately. Our doctor decided instead to administer a depot of medrol. He said it was not really as good as the pred syrup, something about the medrol depot not being equivalent in dosage as it releases steadily for 6 to 8 weeks rather than surges of the medicine at each individual dosage of the syrup. Can someone explain why prelone syrup is better than the longlasting medrol shot? I.E. why are surges of medication better than constant medication? With pred we have had to wean off the dosage. Does the depot wean itself off by gradually diminishing the medicine releasing into the blood? Anyways, this route seems to be doing the trick so far (it has been about 2 weeks). Thanks. Charlene [Posted in FML issue 1453]