Becki and Escher, With bilateral adrenal gland tumors most surgeons remove 1 & 1/2 adrenal glands. The majority of ferrets can live a normal life with 1/2 of an adrenal gland and not require any medication. If both adrenals are completely removed it is likely that the ferret will require lifelong medication (prednisone and/or Florinef). There have been reports of ferrets who have had both adrenals removed and have not required medication. The possible explanations include incomplete removal of both adrenals (getting the entire right adrenal gland is difficult when it has wrapped around the vena cava) or production of adrenal hormones in other tissues (not known where). Dr. Weiss 301-299-4142 [Posted in FML issue 1288]