To Judy Gallipeau: Another surgical fallacy - you can't just look at an adrenal and say it's normal - doesn't matter how good a surgeon you are. I often see proliferative adrenal lesions in adrenals that look grossly normal. If you can conivnce them to run the test - it'll take a month to get the test results back due to the long time it takes to prepare the material - this will tell you not only if the estrogens are elevated, but also if they are coming from the adrenals (as several pre-hormones from the adrenal are being tested for). You shouldn't be at your wits end, because your vets haven't done all of the diagnostics available yet. REmember - the most common source of elevated estrogens in ferrets is adrenal disease - but aside from loking at the adrenals and saying "Hey, they don't look too big", this aspect really hasn't been investigated yet. -- Bruce Williams, DVM, DACVP Department of Veterinary Pathology [log in to unmask] Armed Forces Institute of Pathology [log in to unmask] Washington, D.C. 20306-6000 (202) 782-2600/2602 [Posted in FML issue 1201]