Anne and Adele, Normally we do not diagnose Lymphosarcoma (LSA) on the basis of a blood test alone. An elevated lymphocyte count (>55% or >3,500) is suspicious of the disease. Other symptoms that increase the index of suspicion are the symptoms, including weight loss, poor appetite, lethargy, diarrhea, enlarged lymph nodes. The only way to confirm a diagnosis is with a biopsy or cytology. These samples are sent to a board certified pathologist like Dr Williams. Once the diagnosis is confirmed then treatment is considered. I have seen a fair number of cases of ferrets with an elevated lymphocyte count with and without symptoms, that have a chronic infection and the count goes back to normal after a 14 day course of antibiotics. I would not recommend treatment for LSA without a confirmed diagnosis. (This is one possible explanation for cases of LSA being cured with diet or herbal remidies) Dr Weiss 301-299-4142 [log in to unmask] [Posted in FML issue 1192]