Dixon - the signs that you describe as far as hair and weight loss are consistent with adrenal disease, however, the signs of nervousness are not. Adrenal disesae in the ferret is the result of excessive secretions of estrogen, not corticosteroids, so hyperpexcitablility has neither been seen nor is to be expected. Itching has been suspected to be related to this syndrome, but it has never been proven, so the itching may be a clue to Scooter's continued problem. Some ferrets, however, do respond with behavioral changes following the stresses of intensive medical and surgical care. Generally, this type of behavior is cure with time and care, but sedatives do not fix the problem - they only give you a dopey ferret. I wish I could be of more help. Bruce Williams [log in to unmask] ______________________________ Reply Separator _____________________________ Subject: Adrenal Disease and hyper nervousness Author: "Dixon H. Harris" <[log in to unmask]> at INTERNET Date: 11/23/94 4:23 PM Date: Wed, 23 Nov 94 16:23 EST From: "Dixon H. Harris" <[log in to unmask]> To: "[log in to unmask]" <[log in to unmask]> Cc: Bruce Williams DVM <[log in to unmask]> Subject: Adrenal Disease and hyper nervousness Message-Id: <[log in to unmask]> I have an older albino male who had an adrenal gland excised last March. In July "Scooter" showed distinct symptoms that he had a tumor on both glands.( Weakness, hairloss, etc. The Doc put him on a regimin of lysodrin to counteract the overproduction of glandular secretions, and steroids to get his weight back.) He is off both now. His weight is recovered but his life is much diminished and cute personality changed by extreme nervousness. Scooter shakes and quivers constantly, exhibits fits of nervous scratching almost like a nervous tic, and is extremely sensitive to sudden noise. He hates to be picked up now. The Doc here is a Dallas suburb who has a pretty extensive ferret practice, told me he has seen many such cases, The loss of almost all body hair is not uncommon. But he has never seen such nervousness in other cases. He put Scooter on sedatives; first phenobarbitol, It worked minimally. Now we just started Diazipam ( veterinary Valium). I'm sending this to the FML at large and a copy to Dr Williams. Anybody have any ideas what we should do or where we should go from here to get our old Scooter back? [Posted in FML issue 1023]