We spent several tense hours on May 24th at the Animal Emergency Center in Timonium, Maryland. Ben and Jerry, our two 4 1/2 year old jills, had severe reactions after receiving distemper vaccinations (Fervac) a few hours earlier. They received the shots at 5:00 p.m. We were a little concerned because last year, they vomited almost immediately after their shots. This time we waited at the vet's office for about a half hour in case they would need an antihistamine shot again. They seemed fine, so we took them home. About 3 1/2 hours after the shots, Jerry started vomiting violently and wheezing. When we picked her up, she felt warm and very limp. Our veterinarian's office was closed by this time, so I called the Baltimore Ferret Club president, Diane Rogers, and was advised to go to the Animal Emergency Center. We put all three of our ferrets in their travel cage (in such a panic that we forgot the litter box) and drove as fast as possible to the clinic. Jerry was so weak and limp that we were afraid we would lose her. She perked up a bit by the time we got to the clinic. She was treated with steroids (dexamethicone?) and subcutaneous fluids and was kept under observation. At about 10:30 p.m. (5 1/2 hours after the vaccination), Ben started vomiting and wheezing, so she was also treated. Our 5-month-old, Buttercup, did not develop any problems other than sleepiness. We finally got home at about 1 a.m., exhausted but relieved. The next day, the ferrets seemed less energetic than usual, but otherwise healthy. How common are reactions that require emergency treatment? Should we just never get Ben and Jerry vaccinated for distemper in the future? Should we go back to Fromm D, which was used when they were younger and caused no problems? Dr. Williams or Dr. Brown, we are especially interested in hearing your opinion. Clare & Bill Sebok [Posted in FML issue 0845]