Hi All, I'm reporting this to the group in hopes of finding information if anyone has experienced this and what treatment did they use if any and what was the end results. I'm looking for alternative to conventional treatments. The tumour in his neck is not removable. I have a middle-age male Ferret that came to me with a tumour in his ear it was removed and has now come back. After the removal of the tumour in his ear a mass started to grow in his neck. A biopsy concluded both are cancerous but inconclusive if it started in the ear and made it's way to the neck. Below are the biopsy reports. ----------------- Mass from right ear canal, attached to caudal wall Biopsy DESCRIPTION/MICROSCOPIC FINDINGS/COMMENTS: DESCRIPTION The mass is a ceruminous gland carcinoma. It is a polypoid mass with an ulcerated surface that is covered by fibrinosuppurative exudate. The core of the mass is tightly packed irregularly dilated cysts that often have papillated linings. They contain eosinophilic fluid. The supporting stroma is dense collagen that contains infiltrates of pigment-laden macrophages. The neoplastic cells are mostly cuboidal to columnar, but there are areas where the cells are angular to polygonal. They have discrete borders and abundant eosinophilic cytoplasm. Nuclei are round with a stippled chromatin pattern and most cells have one or 2 small nucleoli. They exhibit about twofold anisokaryosis. In a few areas, the tumor cells have a solid growth habit forming small round nodules. In these nodules, there are up to 4 mitoses in a single high-power field. Affected tissue is at the inked margin. MICROSCOPIC FINDINGS 1.CERUMINOUS GLAND ADENOCARCINOMA COMMENTS As you know, these tumors are infiltrative and locally destructive. They may metastasize to regional lymph nodes, but distant metastasis is less comments. [SIC [mod]] ------------------ Mass (neck) Large mass in neck 2014. Adenocarcinous removed from ear October 2013. Received: Multiple fragments - all processed. Biopsy DESCRIPTION/MICROSCOPIC FINDINGS/COMMENTS: DESCRIPTION The Tru-Cut biopsies have captured an adenocarcinoma. The neoplastic cells are hyperchromatic cuboidal to columnar epithelial cells that are arranged in variably sized tubules. Many of the tubules contain eosinophilic fluid. The cells have a high nuclear to cytoplasmic ratio and up to twofold anisokaryosis. Mitotic figures are sparse. The tumor cells are growing within a very dense collagenous stroma that contains infiltrates of neutrophils, a few lymphocytes and plasma cells, and numerous hemosiderin-laden macrophages. In a few areas, the cells are infiltrating in small clusters and as single cells throughout this dense stroma. MICROSCOPIC FINDINGS 1.INVASIVE ADENOCARCINOMA COMMENTS Unfortunately, the biopsies have captured a scirrhous adenocarcinoma. The exact cell of origin cannot be determined with these samples, but it is possible that it is related to the previously excised mass. Is this mass located in the neck near the base of the same ear where the previous carcinoma was excised? I looked for evidence of lymph node architecture that would suggest that this is a metastatic focus, but none is present here. If the mass is near the angle of the jaw, then a salivary origin is possible. Thanks [Posted in FML 8064]