I've been using Lupron for my adrenal ferrets for the past 10 years and have been pretty happy with the results. my vet is suggesting that I try using the deslorelin implants ( http://www.virbacferretsusa.com/about-suprelorinf-implant ) for my ferrets instead. I've looked up posts from the FML & FHL on the implants, but am not seeing a lot of information on long term use. I'm just wondering if anybody has experiences with using the implant long term (2 years or more), if it works, and how well it worked for them. I'm also curious to know if anybody had the implants not work for their ferrets. My understanding is that the implants last about 6-8 months (although the manufacturer recommends new implant every year), and generally are not removed, so any ferrets that have have been on the implants for more than 2 years will have 3 or more implants (or do they really dissolve as manufacturer says?). Another thing I'm curious about is dosage. Lupron works for my ferrets at different dosages, some ferrets needed a fairly high dose to before seeing its effects. Deslorelin is one dose for all ferrets regardless of size, so how does this work? Do you replace implants for larger ferrets more often? what do you use as a reference for when you need to put in a new implant? For the record, I have been happy with using medical means to manage adrenal disease in ferrets before resorting to surgery, so I am not looking for recommendations on getting surgery instead of deslorelin or lupron. Thank you for any information you care to share. Selina [Posted in FML 7789]