Please everyone continue to share information. And please, those responding, keep it polite whether you agree or disagree. Sometimes when we can't reach the same agreement after sharing our information, we need to politely agree to disagree. We use the same type of lupron (not depot) that Ann does and we've also seen that it works, also, others that I know that use it have too. This has long been a controversial subject. I've discussed it many times with our vet and we are treating based on results we've seen in using it. Whatever the science behind it, I can honestly say in our experience, it does have mixed results (as to working - though I've personally not seen it made symptoms worse) and I've also seen the same mixed results with Lupron Depot and Deslorelin. Bottom line, each of us needs to talk to our vet, research the information (scientific and empirical), then make our own decision on how to treat adrenal disease in the ferrets in our care. Thank you. Respectfully, tle www.ferretfamilyservices.org [Posted in FML 7724]