Hi Leah: Here is an article I wrote about various adrenal disease treatments, including Deslorelin implants. http://www.ferret-fact.org/AdrenaTreatments.htm I treat adrenal disease in my ferrets with both a Deslorelin implant and a melatonin implant. The length of time that the Deslorelin implant remains effective is NOT based on the gender of the ferret. It's based on how advanced the disease is, and the size of the adrenal tumor or tumors that are being treated. A year is a reasonable amount of time to expect it to be effective IF you're dealing with early adrenal disease. However, you've been treating your ferret for 2 years already, so to be safe, you'd probably want to re-implant with Deslorelin in another 6-8 months, depending on when or if you see adrenal symptoms start to show again. Melatonin implants should be done every 4 months, if not a little sooner. Lupron Depot and Deslorelin work in a similar way, so using both would be redundant. However, melatonin works in a different way, so using both Deslorelin and melatonin implants really hits the adrenal tumors as hard as you can medically. Jeff In Loving Memory of Neo, Trinity, Morphy, Baby Girl, Dozer, Possum, Pip, Pop, Sabrina, Minnie Mouse, Hunny, Misty, Frodo, Baggins, and Mr. Parker Caring for Luna, Boomer, and Zoomer [Posted in FML 7683]