Thank you all for your responses! Sorry I didn't put enough information in there to help a lot of you out. I will try again! The pred I have is actually prednisolone and not prednisone, sorry. And the bottle is somewhat confusing. it says 42 cc of Prednisolone per ml. I'm pretty sure a cc and a ml are the same thing, so I'm thinking there was a typing error in there. Regardless, I called my vet and hope to get some more info today when she calls back. I don't have him on any stomah protectants. Our vet hadn't mentioned it and I read some articles online so I have been giving him the meds after he eats for any GI upset. We started supplementing his diet (Marshall's premium) with duck soup (Marshall's "Uncle Jim's"). He has the exact same appetite and same energy levels and weight so I'm just kind of lost. We were doing cherry pepto bismol for the couple of weeks when his odd poop would be diarrhea, but the rest were okay. I started him back on that today. It seemed to work fine, but I thought I was just treating a symptom and not the problem so thats when we took him back to the vet. I will try hemorrhoid cream for his butt and maybe that will help him stay put when he poops. He has been missing the litter box almost every time. The poop itself isn't the worst smelling and are a light brown/dark green color. Though I can only tell this when he goes out of the box because in the box the liquid is absorbed and it looks like he just peed... It is seedy about 75% of the time, which is undigested protein I believe. She had said his levels are low from the lack of absorption. So we started the duck soup and started giving him some treats back (except the ferretlax of course). He seems to be eating and drinking often enough. They have their own bedroom/closet/and bathroom (very spoiled) and 3 different ways to get water so it's hard to tell, but he is urinating every time he poops and his mucous membranes are moist. The other thing that makes me think it isn't a GI infection is that I have 2 other babies, around the same ages, and they share a room together. They eat and sleep and play together 24 hours a day. If one was sick, wouldn't the other 2 have caught it by now? The other two are perfectly healthy with rarely a bad poop. When it first started happening we took every treat away from him. We give them ferretone, ferretlax, ferret vite, ferret chew treats (the sticks), and bandit tartar control treats. We slowly added one in at a time and it seemed that the one he was best with was the tartar control treats so that was all he got for about a month. The diarrhea came back on so we thought it must be something other than a food allergy. He has been on Premium Marshall food since he was 8 months old. The lady we adopted him from was feeding him cheap cat food, but it's been over 3 years so I think that would be out of his system. :) I think I will try adding pure pumpkin or pysllium to his duck soup. I'm not sure what is meant by pure pumpkin though. Just buy a pumpkin and mash up some of it up? I have always been under the assumption that any fruit or vegetable is bad for them so they do not get any food that is not meant for a ferret. I see that the pysllium comes in different forms, is there a brand/type that works best for ferrets? Thank you very much for responding and any help you can give! I hate to see him unhappy, but really the time he seems at all unhappy is when we give prednisolone. [Posted in FML 7672]