Regarding Shron's post re: hair loss after the Des implant. Back in 2008 I took three of my ferrets to Pittsburgh to be part of Doc Wagner's study. It was in the fall of the year and Luke had been in a shelter with untreated ACD. I offered to take him to Pittsburgh for an implant and pay for it (he then was adopted by us - big surprise right?) Anyway, while we knew he was adrenal, he had thinning of the fur in the standard locations, Doc held Luke and just before implant he grasp some fur between his thumb and forefinger and pulled out a gob of fur, remarking, "See this, this is adrenal disease." I thought, don't do that it is getting cold Luke needs all the fur he has! My point is, even if ferrets have not lost enough hair to have thinning or balding spots, it doesn't take much once ACD has begun for the fur to be rubbed out on objects or from handling. I'm curious if you ever had an ultrasound performed on Minky to get an idea of how involved the tumor activity was? US can show the size of the tumor, how much of the vena cava is impaired if it is a right adrenal tumor and if the tumor is attaching to other organs. Also, were you ever able to have a necropsy done following Minky's death? Ferrets can have many underlying illnesses that are so well hidden, without a necropsy or pathology report done to determine cause of death one has to be careful to not assume for example; that Minky died of ACD or the use of the implant or Lupron. It is possible that Minky's ACD was more advanced than you realized and he could have had a number of internal issues form large tumors. If he lost hair shortly after the implant I would almost suspect this case as the study has consistently shown hair re-growth between 8 and 12 weeks. Without either of the two procedues mentioned above, I'm not sure you will ever have a solid answer. The nice thing about an ultrasound (if you can get them done from a vet charging affordable fees) is that the tech can locate and measure the tumors and snap a pic with measurements on it to use as a baseline. My Jille who is 8 just got her second implant (I screwed up and was 4 months late getting it for her). In 14 months her tumor grew less than double its starting size, there was no impairment to the vena cava and it has not attached to any other organs; all positive feedback. Hope this information is helpful. God Bless Minky and his cagemate who passed. CAthy Feed rescued animals in two clicks http://www.theanimalrescuesite.com/clickToGive/home.faces?siteId=3 [Posted in FML 7564]