After receiving a few responses to my post, I wanted to share the following which I didn't add yesterday. Pet Health Pharmacy also utilizes sesame oil in the Prednisolone and the diazoxide compounded meds. Their directions recommend rolling the bottle from side to side prior to usage - not shaking the bottle. I have found that if I store the bottles on their sides (after being certain tops are screwed on tightly) the powders do not tend to settle into the nooks and crannies of the bottom of the bottle. I find this difference allows me to get use of all of the med. Other brands have separated and seemed to become thinner toward the end of the bottle. Hope this helps. Cathy Feed rescued animals in two clicks http://www.theanimalrescuesite.com/clickToGive/home.faces?siteId=3 [Posted in FML 7559]