While we're on the subject... It is beyond my understanding why a vet would even prescribe prednisone instead of prednisolone for a ferret. Is there a logical reason for doing this, other than to save a little money? But why even take the chance that the sick ferret won't be able to properly metabolize the prednisone into prednisolone, which is the form of the drug that the body uses? Some ill ferrets whose livers are compromised cannot make use of the prednisone, whereas prednisolone is metabolized and used quite well by the body of those same ferrets. Perhaps there are just not enough 'really good' ferret vets who understand this. And, in that same vein, why wouldn't all vets also prescribe that the prednisolone be given 3 times a day, every 8 hours, instead of twice a day, every 12 hours? If indeed the prednisolone is used up by the ferrets body in approximately 9 hours or so, as I have seen written by some vets, then twice a day your insulinomic ferret has a 'window' of about 3 hours during which his or her body is really not being protected, and thus is very much susceptible to seizures. I have had several ferrets with either insulinoma, or worse, carcinoma of the pancreas, and NONE ever had a seizure. Not even at the end, when the dose of prednisolone was very high. I follow two simple rules. I use liquid prednisolone, NEVER prednisone. And, I always give the dose every 8 hours, or darn close to it, NOT every 12 hours. So, when I read that a ferret is having seizures from insulinoma (or from a pancreas that is compromised by carcinoma or lymphoma), I wonder if those seizures could really be avoided fairly easily with a little more knowledge given to the owners. Jeff In Loving Memory of Neo, Trinity, Morphy, Baby Girl, Dozer, Possum, Pip, Pop, Sabrina, Minnie Mouse, Hunny, Misty, Frodo, Baggins, and Mr. Parker Caring for Luna, Boomer, and Zoomer [Posted in FML 7474]