Great topic! I'm eager to hear peoples advice. I can tell you that there is a difference between taking an extended vacation with ferrets and a day trip or overnighter. If you are going to be on the road a very long time, and your ferrets aren't used to that regularly, you might want to try to prevent motion sickness. I've never experienced that with a ferret or known of one with it, but certainly you dont want to take the chance. They can spiral downward so fast with dehydration. One trick to prevent motion sickness in animals is to cover up the side windows so they can only see front and back. I actually like to cover all sides except for the front (where I can see them and where they can see out the front window). You can do this rather easily just by draping blankets over their travel cages. There must be something you can put in their water to also help. However, something like ginger might deter them from drinking. Perhaps some ginger sprinkled in their food. Troy Lynn knows about ferrets, nausea and use of ginger. Because ferrets sleep all day, taking them out for exercise is not a necessity. It can be dangerous in a car in fact. Its safer to put them on leashes and take them for a walk at a rest area. But honestly? If you want to relax and to eliminate any accidents, leave them in the cage. They wont "die". Promise. Renee Downs might have some input on the safest type of travel cage to use. Her cages were put to test as her SUV rolled down an interstate in a tragic accident. Do not have open bowls of water in the cage. However, do have bowls that attach to the cage under water bottles because the vibration and shaking will make them drip which will be a mess. Keep a low level of food in the bowl so they dont dig it out when bored or irritated. Of course bring any medications they may need. Lots and lots of clean hammies and bedding is a big help. They tend to sleep more, and it can keep odor down. Speaking of which, might want to bath them before going. Being trapped in a car for many hours with ferrets can get peoples allergies going. If you have given your ferret a bath within the last month or so, you might want to use Marshal Farms Creme Rinse if you choose to bath them again before the trip. That stuff is awesome. It moisturizes their skin so they dont tend to itch or get smelly after a bath. It makes them ever so soft as well. Pretty much take a smaller version of their cage (if not their cage), fully loaded when going on a long trip. Bring along their own food, and much more than they will eat in case you get stuck. Have leashes ready in case you are in an accident or break down. Might want to have pillow cases too. I'm not sure what to do about air conditioning if you are having a heat wave. You dont want to break down in 100 degree weather with a ferret. Perhaps plenty of ice in a cooler and heavy duty zip lock bags (to put ice in, and to put in their cage) might help in such an emergency. Dont stress about this. This is fun. Ferrets are hardy travelers! But for your own peace of mind, you might want to "have and not need" rather than "need and not have". Man. Whole lotta talkin' here with very little advice. Hope others chime in. Wolfy [Posted in FML 7441]