HI Pam: This is a VERY serious condition that you need to get under control immediately if at all possible, or it could suddenly and painfully take his life. What you MAY be describing is proliferative colitis, and I recently lost my boy Dozer to this after he battled it for several months. It usually afflicts younger ferrets, but on occasion can occur in older ones (Dozer had just turned 4 years old). The last month before I had to put him to sleep on Nov 20 was just horrible. I had two excellent vets, plus another outstanding consulting vet, and we tried EVERYTHING, including exploratory surgery and having two biopsies done. He had to be on heavy pain meds for the last couple of weeks as we tried the last treatments that we could think of, because when he wasn't well sedated, all he did was try to squeeze and poop when there was nothing to squeeze, to the point of physical exhaustion, and he was in clear pain while doing so. I can talk to you more privately if you'd like, but what I would suggest is that you talk to your vets right away about trying Chloramphenicol (twice daily) as an antibiotic, for at least a month, and also using prednisolone (probably around 0.5 -- 0.75 mg twice daily) to try to get the inflammation down and his colon back under control. You may also need to use carafate to prevent further ulceration from the condition and from the prednisolone. This is a very serious condition that will not improve on its own and could worsen suddenly to the point where you could lose him. Jeff In Loving Memory of Neo, Trinity, Morphy, Dozer, Possum, Pip, Pop, Sabrina, Minnie Mouse, Hunny, Misty, Frodo, Baggins, and Mr. Parker Caring for Luna, Baby Girl, Boomer, and Zoomer [Posted in FML 7285]