We have had several ferrets, about 8 now, that have been treated using the Tufts protocol. We had a small shelter and even with our discounts it can get expensive. Typical treatments range from $30 -$120 per visit with higher cost in the first few weeks. The treatments last 31 weeks total and we have not had one that didn't make it at least a year once the treatments start. We have on currently that finished her treatments about 6 months ago and she is still a full out ferret. We usually see a marked improvement by the 3rd treatment. Although we usually drop the ferrets for the day on the first couple of treatments we have yet to see an adverse reaction. IMHO it is a must to try this treatment. If you don't see an improvement by the 2nd or 3rd treatment reevaluate but give it a shot. Ken Nyren [Posted in FML 7127]