Adrenal treatments can be completely safely given to most ferrets with insulinoma. Where things can get tricky is that a small minority -- about 5% -- of ferrets with adrenal growths also have the cortisol overproduced. In that case, treating the adrenal disease will allow the insulinoma to show itself more -- and that is treating it in general, not in just any one way, though some approaches are more effective and therefore can have more effect in this way, too. If the insulinoma is severe then that is a strong concern to discuss with your veterinarian, but if it is not then medications for the insulinoma can be adjusted so you and your vet simply have to take into account that this does happen, but rarely and be prepared just in case. Again, remember that about 95% of the ferrets with insulinoma and adrenal disease do NOT over-produce cortisol. This is also why those meds can help some ferrets who have diabetes. There are also considerations that are taken into account for surgery, including special ones when insulinoma is already present, as well as special Addisons concerns and meds for the minority of ferrets who have an atrophied adrenal and have the other removed or loss both completely, etc. Sukie (not a vet) Recommended ferret health links: http://pets.groups.yahoo.com/group/ferrethealth/ http://ferrethealth.org/archive/ http://www.afip.org/ferrets/index.html http://www.miamiferret.org/ http://www.ferrethealth.msu.edu/ http://www.ferretcongress.org/ http://www.trifl.org/index.shtml http://homepage.mac.com/sukie/sukiesferretlinks.html all ferret topics: http://listserv.ferretmailinglist.org/archives/ferret-search.html "All hail the procrastinators for they shall rule the world tomorrow." (2010, Steve Crandall) [Posted in FML 7097]