Hello all, This discussion proves you're never too old to learn. I had always believed that if Melatonin regrew fur, then it was affecting the adrenal glands and reversing any damage. WRONG! I've never gone the Lupron route, if Melatonin didn't work or the fur loss was too severe, I always go for surgery. As of now, out of the 22 or so ferrets I've had, only one has never needed any type of treatment for adrenal disease and has never developed symptoms, KNOCK ON WOOD. The point of my message is that if you can afford the surgery, do the surgery. If you can't, a combination of Melatonin and Lupron appears to be the best alternative. Leslie [Posted in FML 6986]