All of our fur children receive distemper and rabies vaccines. No one reacted their first time. However,we have had three reactions since-two to distemper and one to rabies. All were moderate to severe. Our vet recommended discontinuing the reaction-causing vaccinations for the three affected ferrets. While not an extreme blow, we do show all eight once a year. Unfortunately, the two who reacted to distemper will most likely be attending their last show in april as distemper vaccines are required for entry. Our champagne, isabelle, has done very well at the ferret den's ferret fiesta, even taking best of show (honestly, one of the most exciting moments of my life. I was literally jumping up and down.) We really wanted to go to buckeye bash with her. In order to do this, we'll have to attend this year, before her rabies booster expires. It also concerns me in case she would ever bite. She's never been anything but a sweetheart, but sometimes things happen. I'm definitely more concerned about reactions now. I'm sincerely hoping all future boosters can be given without incident. But, after what's occurred this year, even with no previous reactions, i'm not expecting this. You just never know how they will handle their vaccines. Abby and Ryan, proud ferrents of Edward, Daisy, Ozwald, Clyde, Isabelle, Penelope, Oliver and Benjamin [Posted in FML 6952]