http://pets.groups.yahoo.com/group/ferrethealth/message/14280 (The original post asking the questions also appeared in the FML, hence the name left on.) Hi Becky I have used close to 1,000 melatonin implants and have not seen an allergic reaction or anything like your ferret's experience from the melatonin implants. As you and your vet should know, the implants do not dissolve (ie once they are implanted the implant remains there for the rest of the ferret's life), and you do not have to remove the old implants. It is also unlikely to have an allergic reaction to melatonin. If your ferret is allergic to melatonin it would have an allergic reaction every night when it naturally makes its own melatonin. Likewise it would have an allergic reaction everytime you give the melatonin tablet. The 62 mile car ride, the 2 hour visit to your mom's house, a vaccine, or something else is the likely cause for Snowball's problem and not an allergic reaction to melatonin. Hope that helps clear things up, Jerry Murray, DVM ---- http://pets.groups.yahoo.com/group/ferrethealth/message/14281 You are using a quote from Dr Wagner's paper about the 3 mg deslorelin implant. Fortunately the 4.7 and the 9.4 mg implants do not have the same side effect of a high rate of adrenal carcinomas after the implant wears out. BTW the company no longer makes the 3 mg implant. Hope that helps clear things up, Jerry Murray, DVM (Sukie note: I am wondering if this happened due to a mechanism which has been described for another drug in the same class in http://www.miamiferret.org/24hr_lupron.htm ) Sukie (not a vet, but an FHL moderator with permission to do such cross-posts that may help others) Recommended ferret health links: http://pets.groups.yahoo.com/group/ferrethealth/ http://ferrethealth.org/archive/ http://www.afip.org/ferrets/index.html http://www.miamiferret.org/ http://www.ferrethealth.msu.edu/ http://www.ferretcongress.org/ http://www.trifl.org/index.shtml http://homepage.mac.com/sukie/sukiesferretlinks.html all ferret topics: http://listserv.ferretmailinglist.org/archives/ferret-search.html "All hail the procrastinators for they shall rule the world tomorrow." (2010, Steve Crandall) [Posted in FML 6935]