Hi There, It's Marlene at RFRL- we've been using Lupron since 1999- our vet gives the 30-day depot injection,and he gives the entire 500 micrograms. We've found that: A) we're always seeing the symptoms disappearing from 14-16 months and sometimes longer, B) the older the ferret, the less effective the Lupron. The oldest ferrets we've given Lupron were both 8 years old- One was a late-alter "retired" breeder ferret- he lived another 8 or 9 months after his Lupron, the the other ferret was a simple MF boy. Again, he lived a few months later, then went peacefully in his sleep. The reason we opted to give Lupron at these "Ripe" old ages? Both ferrets were males- hence, swollen prostates, blockages, etc. I know many vets offer monthly Lupron injections, or will only give as much as the 100- 200 micrograms. Vets are just like so-called "real" doctors, they all have their own opinions.... But these are the results we've had since 1999. Sincerely, Marlene Blackburn Director RFRL www.richmondferretrescueleague.org [Posted in FML 6599]