Ferrets do NOT normally have problems with adrenal surgery as long as the vet is good, there is proper post-op care at home, the ferret is not one of the rare ones who have to adjust afterward to having the Vena Cava ligated, AND if there is care taken to provide replacements for needed adrenal products if both adrenals are removed completely or mostly, or if one is atrophied. Those usually are just either Fludrocort/Florinef AND Prednisolone, OR Percorten AND Prednisolone. Some of those also need some extra salt in the diet until the right dosing is found. They can also need extra of their meds when under strong stresses. There seem to still be too many people who let ferrets climb (even small amounts) after surgery in the first 2 weeks, don't keep them hydrated and fed post-op, or otherwise do things that can kill after surgery. There also seem to be too many vets who rarely handle ferrets who don't know how and when to replace adrenal products. The amounts needed of the meds is small, BTW. I am under the impression that one resource might have wrong dosing given what one vet thought would be needed. There is a lot on post-op or post-surgical care in the archives of both the FML and FHL, and i sent you some resources yesterday. When going non-surgically melatonin is a help but only a minor one compared to other meds that is can and should be used ALONG WITH like Lupron or deslorelin. Sukie (not a vet) Recommended ferret health links: http://pets.groups.yahoo.com/group/ferrethealth/ http://ferrethealth.org/archive/ http://www.afip.org/ferrets/index.html http://www.miamiferret.org/ http://www.ferrethealth.msu.edu/ http://www.ferretcongress.org/ http://www.trifl.org/index.shtml http://homepage.mac.com/sukie/sukiesferretlinks.html all ferret topics: http://listserv.ferretmailinglist.org/archives/ferret-search.html [Posted in FML 6418]