Hi Mary, I had a similair problem with my Loki (who passed in May due to her Lymphoma). Due to the Lymphoma, she was full of fluid (at the time of her death-she had gone from her healthy weight of 1.5 lbs to almost 2 1/2 lbs (all fluid). She actually had "butt cheeks". We tried different things--to no avail--but, what seemed to work the best (it helped, but never made the irritation go totally away for any extended amount of time) Was a very dilute betadine (to wash the area--I used a squeeze bottle to make it the least irritating as possible) then I would air dry as well as possible-pat dry lightly if I had to and then put animax on it. I hope this helps--I know how hard it is looking at your baby knowing he/she is uncomfortable, but not being able to find the right combination to fix it. Good luck! Michele Paulhus -- "People are like stained-glass windows. They sparkle and shine when the sun is out, but when the darkness sets in their true beauty is revealed only if there is light from within." ~Elisabeth Kubler-Ross~ [Posted in FML 6235]