Kimberley, You don't mention whether you also stopped the Lupron, when you stopped the Melatonin nor what the side effects were that compelled you to stop giving it. Perhaps you had posted that information earlier and I missed it. I understand that given his advanced age he is not a suitable surgical candidate. However, he needs to be kept on Lupron at the very least, especially if he's at risk for a blockage from the enlarged prostate. A ferret with a blockage will die painfully within 10 hours if there is no intervention. If he is starting to experience problems urinating and you already know he has an enlarged prostate it is critical to get him on the Lupron asap. He may also have developed a concommittent urinary tract infection. Has a urine culture been done? A large gib requires at minimum 200 mcg. (or more) of the one-month Lupron Depot. Herbs and supplements like Saw Palmetto work fine if taken in conjunction with Lupron and/or Melatonin but are not a substitute for either. Tressie Tressie A. Dutchyn, ID PhD (c)Dalhousie University Research Project Coordinator Community Health & Epidemiology Faculty of Medicine tr [Posted in FML 6117]