Personally in ten years of owning ferrets I haven't heard of anyone having surgery for this with any real results. The pancreatic tumors are so tiny that I would think removing them would be very difficult and it would also be very difficult to know if all have really been removed. Plus more will most likely grow. I've had two ferrets with insulinoma that showed up around 3 or 4 years old and both lived another year and a half to two years with Pred twice a day. I would think the only the real chance of success with surgery would be if the disease was caught VERY early before the tumors have really started to grow and multiply. Here's a site with some more info http://www.ferret-universe.com/health/insulinoma.asp#surgery Laura [Posted in FML 6061]