Leah: Pred is metabolized by the ferret's system within about 8 hours. If you only give it to him every 12 hours, then he has approximately a 4 hour window twice daily when his body is without the protection of the Pred to fight off the extra insulin that it produces. His Blood Glucose then will dip and he will have no energy. I would strongly suggest that you divide his daily total dosage of Pred into 3 doses, 8 hours apart, rather than 2 doses, 12 hours apart. Also, make sure that he has food available to him all the time. Insulinoma is a progressive disease. It only gets worse. Thus, his daily TOTAL dosage of pred will have to increase over time. A BG level of 70 is still on the low side, and he should probably be getting enough Pred daily to maintain a level of 80 or higher. 90 - 110 is the 'normal' range. Finally, if he's getting Prednisone, not Prednisolone, then you should switch to Prednisolone. It is easier for their body to metabolize and use, and easier on the liver. Jeff In Memory of Neo Caring for Trinny, Morphy, Baby Girl, and Luna [Posted in FML 5976]