We use Revolution once a month during mosquito season. Approved by our vet and by other prominant vets online (see Ferret Health List archives). Kills ear mites, fleas, ticks, and prevents heartworm. The proper size to use to prevent all of these, including heartworms, is the cat 5-15 lbs. size. Heartworms are spread by mosquitos, which is why we use it during mosquito season. Jeff In Memory of Neo Caring for Trinny, Morphy, Baby Girl, and Luna [Posted in FML 5976]