I was also told lupron had to be injected into the leg/thigh area. I printed out anatomy pages and learned. BUT - the reason vets do it subq is because it works, and you have a very large chance of paralyzing/damaging the leg if you do it in the thigh if you have nothing to really work with, no big muscles. I've done a leg injection on a very large female where I could tell exactly where to go. It worked just fine. But, that's not for the faint of heart and I really don't recommend it. I did it before I realized that subq works just as well according to most veterinarians. On a male ferret, I did subq. The thing is, he developed a very large lump that became red, and then orange, with orange crust. Terrified, I went online and asked if anyone else had encountered this; a few people said yes, one person said yes to the orange, and suggested compresses. Of course since they are totally different ferrets, and only two, I can't possibly compare the results (leg to sq). Laryssa [Posted in FML 5960]