Congratulations on your adoption and to your fuzzone who just got a happy forever home! When my ferret Mikette was first put on prednisone (well, she was on prednisolone - the pedia pred) it made her very lethargic. She ended up doing better on a combo of prednisolone and diaoxide (which is expensive, but was given in a smaller dose of the pred). But we did regular blood glucose readings and over time her pred was upped higher and higher, but with the diaoxide she did well despite the increased pred. But over time she was less active. Dooks Risa [Posted in FML 5852]