Sonia: I know it might not feel like it now, but you were lucky. I took my sweet boy, Pedro, in for his distemper vaccine a few months ago and he had a horrible reaction. The vet is very cautious and had pre-treated with benadryl and had us stay there half an hour just in case of a reaction. Sure enough, he had one with a vengeance while we were still there. Our vet did everything humanly possible - even personally transported him back and forth to the emergency clinic after office hours - all free of charge, I might add. None the less, two days later, we lost our baby. Just like you, we felt terrible to have taken a perfectly healthy, happy ferret in only to have this happen, but what do you do? I've had to accept the fact that no vaccine is 100% effective or risk-free. I know that distemper is 100% fatal, but the vaccine was 100% fatal for my Pedro. So, from now on, we will have the distemper titer level test done on our ferrets before vaccinating, and our vet is totally on board with this. The study is being done by Dr. Heller and the AFA and you can find out about it at http://www.ferret.org/news/07-april-titer_study.shtm It's so heartbreaking when something like this happens, but all we can do is try to make the best, most well-informed decisions that we can to care for our ferrets. Take care - Judy Stickley Chelsea, Alabama Owned by: Possum and Emory. Remembering: Pancho, Cisco, Trucker and Pedro [Posted in FML 5785]