There is currently ONE vaccines which is specifically for ferrets: Purevax CD Vaccine for ferrets (It is also used for a number of zoo animals.) That HAS had extensive testing for effectiveness in ferrets, length of effect of at least one year, and safety. Of course, an allergic reaction can happen with anything, but the rate is low. But Galaxy-D is often used. The thing to check for is to make sure they don't change how they manufacture the Galaxy-D. Since they don't sell it specifically as a ferret vaccine if they change manufacture to using ferret cell lines then it could pose a risk. Personally, I doubt they would carelessly endanger the income they have from it being used for ferrets. Galaxy-D was tested for 21 days in a small sample of male kits, but it's predecessor, Fromme-D was far more extensively tested in ferrets. Many use Galaxy-D and we have in a pinch; it is important to just remember what has not been tested in it and to remember to make sure the production isn't altered. Before there were any vaccines specifically for ferrets the ways to find safe vaccines that could not cause Canine Distemper in ferrets was to find ones with killed virus which had not been grown in ferret cell lines. Effectiveness was usually still unknown then (except for some which way back then were tested in ferrets first -- to make sure they didn't kill a bunch -- before being tested in dogs) Forgive typos and if I make a stupid one fix it in your head because i have had 3 hours of sleep. Sukie (not a vet) Recommended ferret health links: http://pets.groups.yahoo.com/group/ferrethealth/ http://ferrethealth.org/archive/ http://www.afip.org/ferrets/index.html http://www.miamiferret.org/fhc/ http://www.ferretcongress.org/ http://www.trifl.org/index.shtml http://homepage.mac.com/sukie/sukiesferretlinks.html [Posted in FML 5757]