Have you checked his health? Get a med and dental check and do a sensory check. Behavioral changes can happen with health changes for the worse, but also can happen with painful social changes (like if one of the other ferrets is picking on him too much), with inadvertent reminders of PAST abuse before you got him, or with sudden sensory loss. When one of ours lost much her vision early we went to adding safe scents for scent mapping (Go to the FHL Archives addy which is the second link below or the FML Archives addy which is in the header of each day's FML because I think the info is there, too, though I am not sure of that.) and also scenting toys, and we got her more adventurous with a rose scented bell mousie on a "fishing line" and using interesting feelings beneath her feet (even bubble wrap). Years ago we let some rescues who had been kicked and beaten beat up shoes till they no longer caused fear, and we noticed that one also freaked if oil cloth was worn so we let her tear into an oil cloth jacket repeatedly till she felt that it posed no risk to her. Oh, and check if any possibly painful noises have been added to the home. --- Has anyone heard any news about the granting of permission for deslorelin/Suprelorin Depots of the right size sfor use in carnivores to be sold in the U.S.? The okay usually takes about 2 years, and being willing to manufacture a drug in the U.S. (which Peptech was at that time of application) usually speeds things, but there has been no news on that score which I have encountered. Meanwhile, for some of the potential ferret uses the work of people like Dr. Bob Wagner of Pitt tells a great deal about treatment and more (as those who attended the IFC symposium will know -- so I wish I could have been there for more details but look forward to buying any data sources later available through the IFC), and the long term work of Dr. Nico Schoemaker of the Netherlands will address further questions (chemical castration, life long adrenal disease preventative use, whether the med becomes less effective over time in ferrets as that class of meds can in humans, etc.) Sukie (not a vet) Recommended ferret health links: http://pets.groups.yahoo.com/group/ferrethealth/ http://ferrethealth.org/archive/ http://www.afip.org/ferrets/index.html http://www.miamiferret.org/fhc/ http://www.ferretcongress.org/ http://www.trifl.org/index.shtml http://homepage.mac.com/sukie/sukiesferretlinks.html [Posted in FML 5669]