Mike, What type of reaction did he have to Pred? Was it to Prednisone or Prednisolone, and in which format? Has Diazoxide been tried? Have a small amount of it compounded for a trial. You can find a list of compounding pharmacies for your vet's prescription in the Files section of the FHL (address in my signature lines). Many ship. We have had only a few ferrets with insulinoma in 26 years and have also encountered lymphoma in the pancreas (which is harder to manage and worsens faster but presents similarly) and carcinoma in the pancreas which is the worst of those three that can look similar. When we have been forced to resort to added dietary sugar (advanced insulinoma, and all through pancreatic lymphoma) we've made sure to that it is ALWAYS available. One trick that worked was to take two forks and work those through Nutrical in water. Then let it sit a while and remove the fat film because the ferrets object to that. Then make that bowl available. Sukie (not a vet) Current FHL address: http://groups.yahoo.com/group/ferrethealth Recommended ferret health links: http://pets.groups.yahoo.com/group/ferrethealth/ http://ferrethealth.org/archive/ http://www.afip.org/ferrets/index.html http://www.miamiferret.org/fhc/ http://www.ferretcongress.org/ http://www.trifl.org/index.shtml http://homepage.mac.com/sukie/sukiesferretlinks.html [Posted in FML 5583]