Hi Jacci I know things are different here in Europe, But in Holland we don't even have a distemper shot for ferrets. We always use the shot for puppies. We have two sorts, the vanguard for pups, this one can be dangerous for ferrets and ferrets have died from it, unluckily some vets do still use it. We also have the Nobivac DP, to my knowledge and that of dr Hanneke Moorman, ferrets have never had reactions or been sick from this shot. Take into consideration that Dr Moorman works only with ferrets, so she sees and vaccinates around 15 to 20 ferrets a day. 4 days a week, I would say the Nobivak is very trustworthy. Good luck Stephenie Stichting "De Fret "Netherlands [Posted in FML 5504]