Candy, there really is NOT enough info to narrow anything down. You mention a very general symptom (weight loss) which can be caused by almost anything from poor nutrition, to blockage, to cardiomyopathy, to lymphoma, and on and on. Two notes: when unsure of what caused a death ALWAYS have a necropcy WITH SPECIMENS SEND FOR PATHOLOGY BY A FERRET VETERINARY PATHOLOGIST ASAP. Some of the digestive tract (and gall bladder and pancreas) info is lost within hours due to self-digestion after death and the longest a ferret cadaver can go before all data is lost is about 48 hours if kept in a refrigerator. Freezing bursts cells. It is fine for certain pathogen tests, but not for study of the tissues so it loses essential data. I am sorry that you seem to be learning this the hard way. What tests have been done and what are the results? Was the first imaged" The second? X-rays or sonogram? What was seen? Was not just a CBC but CBC WITH CHEMISTRY PANEL done on these ferrets and what where the results? What other symptoms are you seeing? What are these ferrets fed (food, supplements of any types, any meds of any type)? What do they have access to? Have you been using a deodorizer in the room? Is there cedar in the cage? Etc. Your next step if testing hasn't been done is to have testing done on the sick ferret while a LOT of supportive care is provided. If you think that the ferret may need help eating or the vet wants you to do sub-cu hydration HAVE THE VET OR VET TECH TEACH YOU HOW. It is possible to sub-cu wrong, and more often it is possible to "force- feed" wrong and cause aspiration pneumonia which can rapidly become fatal. Gentler alternatives are better than force feeding in all but the most extreme cases, and -- again -- the veterinary professionals need to be the ones to teach you how to do these things. -- Sukie (not a vet, and not speaking for any of the below in my private posts) Recommended health resources to help ferrets and the people who love them: Ferret Health List http://www.smartgroups.com/groups/ferrethealth FHL Archives http://ferrethealth.org/archive/ AFIP Ferret Pathology http://www.afip.org/ferrets/index.html Miamiferrets http://www.miamiferret.org/fhc/ International Ferret Congress Critical References http://www.ferretcongress.org [Posted in FML 5403]