If there is also possible insulinoma or diabetes try oral melatonin first to see how the ferret fares. (I recently sent this info, so someone may not have been a member yet just those few days ago.) Veterinary debate and study are ongoing because melatonin serves two opposing functions in the pancreas so it might help some or worsen some with either condition. Right now there is way too little data to know, so this is just a caution "in case" rather than hard data. -- Sukie (not a vet, and not speaking for any of the below in my private posts) Recommended health resources to help ferrets and the people who love them: Ferret Health List http://www.smartgroups.com/groups/ferrethealth FHL Archives http://ferrethealth.org/archive/ AFIP Ferret Pathology http://www.afip.org/ferrets/index.html Miamiferrets http://www.miamiferret.org/fhc/ International Ferret Congress Critical References http://www.ferretcongress.org [Posted in FML 5387]