Becky, Whole males tend to often be much (much) larger than most neutered males, and there are some absolutely huge lines. You should see the size of some of the Russian lines discussed on Ferret-Genetics in Yahoogroups in the past because a few of them will remind you of small cats in size, larger than the 6 pound +, non-obese whole males we saw in Montana years back. Deslorelin Depot/Suprelorin is still considered experimental in the U.S. and available that way, but application has been made for sale here. It lasts longer than Lupron and seem to perhaps work better for some cases, but is not widely available in the U.S. for obvious reasons since it has to be gotten as part of approved experimental investigation. There are multiple studies on the med already, and there is at least one on-going U.S. study and another in Europe (Dr. Nico Schoemaker.) You will want to see these: http://ferrethealth.org/archive/browse.php?msg=SG16945 http://ferrethealth.org/archive/browse.php?msg=SG16127 http://ferrethealth.org/archive/browse.php?msg=SG16126 and more -- Sukie (not a vet, and not speaking for any of the below in my private posts) Recommended health resources to help ferrets and the people who love them: Ferret Health List http://www.smartgroups.com/groups/ferrethealth FHL Archives http://ferrethealth.org/archive/ AFIP Ferret Pathology http://www.afip.org/ferrets/index.html Miamiferrets http://www.miamiferret.org/fhc/ International Ferret Congress Critical References http://www.ferretcongress.org [Posted in FML issue 5202]